NIEHS Director's Update

Riverside: Animal cancer studies using a mouse skin model on co-promotion by 60 Hz EMFs with the initiator dimethylbenzanthracene and the promoter 12O-tetradecanoylphorbol13acetate; * Charles Graham, Midwest Research Institute, Kansas City, Missouri: Human studies on the effects of nighttime EMF exposures on melatonin, other hormones, and the immune system; * Sek Wen Hui, Roswell Park Cancer Institute, Buffalo, New York: Role of 60 Hz EMFs on gene expression, cancer promotion and signal transduction; * Henry Lai, University of Washington, Seattle: Effects of ELF magnetic fields on neurological function and behavior in rats with emphasis on cholinergic activity; * Robert Linburdy, University of California, Berkeley: Role of various AC/DC field combinations in calcium signaling and cell proliferation and viability-a test of the Lednev hypothesis; * Richard Luben, University of California, Riverside: Biochemical mechanisms of 60 Hz magnetic field effects in signal transduction and on membrane receptors in mammalian cells; * Rosemonde Mandeville, University of Quebec, Laval: Copromoting effects of 60 Hz magnetic fields and subthreshold doses of ethylnitrosourea on brain tumors in rats; * David McCormick, IIT Research Institute, Chicago: Influence of EMFs on the proliferation of human breast epithelial cells and on the expression of cancer-associated genes; * Kenneth McLeod, State University of New York, Stony Brook: Role of frequency, intensity and duration of EMF electric field exposures and cell characteristics on the modulation of cell behavior; * Richard Miller, Columbia University, New York: Effects of 60 Hz EMFs on the expression of oncogenes in cancer initiation and promotion in human and mouse cells; * Steven Miller, SRI International, Menlo Park, California: Effects of 60 Hz EMFs on signal transduction in vitro and possible effects on reactive oxygen intermediates in tumor promotion; * Richard Nuccitelli, University of California, Davis: Changes in expression of proteins associated with differentiation of human skin cells resulting from 60 Hz EMF exposures; * Russel Reiter, University of Texas, San Antonio: Impact of sinusoidal magnetic fields on melatonin levels in vivo; search for critical exposure parameters and for role of pineal gland; * Clifford Rinehart, University of North Carolina, Chapel Hill: Effects of 60 Hz EMFs on expression of oncogenes, transcription factors and enzymes related to malignant transformation in cells; * Jeffrey Saffer, Battelle Pacific NW Labs, Richland, Washington: Gene expression studies on the role of various ELF fields in copromoting neoplastic transformation ofJB-6 cells; * Jerry Williams, Johns Hopkins Oncology Center, Baltimore, Maryland: Cellular studies on the effects of EMFs on myc oncogenes, growth enzymes, and carcinogenic and cocarcinogenic processes; * Gayle Woloschak, Argonne National Laboratory, Argonne, Illinois: Identification of EMF-induced genes, the kinetics of their response and the mechanism of the modulation of gene expression; * Steven Yellon, Loma Linda University, Loma Linda, California: Effects of melatonin production and on reproductive development in the Djungarian hamster.